A company with UC Santa Cruz roots called Two Pore Guys has created a biosensing device that may revolutionize the way we do medicine and live in our environment.

It was early 2010 and Bill Dunbar paced the hallway between his office and his lab in UC Santa Cruz’s Engineering 2 building.

A lanky surfer and a drummer with a Ph.D. in feedback control theory, a backbone technology of self-driving cars, Dunbar had come to UC Santa Cruz in 2004 to help bolster the university’s robotics degree program. But a year after he arrived on the wooded campus, Dunbar met David Deamer and Mark Akeson, two UC Santa Cruz professors who were pioneering a way to sequence DNA strands faster and less expensively by using electronic voltage to pull each molecule through a microscopic hole called a nanopore. They had a problem they thought Dunbar might be able to solve.

The quandary Dunbar faced as he stalked that fluorescent-lit hall was that DNA molecules zipped through the nanometer-scale hole like bullets through a gun barrel, making them hard to read. Was there a way to slow them down and maybe even move them back and forth so you could decipher them with real accuracy.

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