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High-throughput Phenotyping of Lung Cancer Somatic Mutations

by webmaster | Aug 8, 2016 | Publications

Abstract: Recent genome sequencing efforts have identified millions of somatic mutations in cancer. However, the functional impact of most variants is poorly understood. Here we characterize 194 somatic mutations identified in primary lung adenocarcinomas. We present...

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

by webmaster | May 9, 2016 | Publications

Abstract: To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined the exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor-normal pairs. Recurrent...

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