by tunhnguy | May 17, 2023 | Publications
Abstract Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals (source). These assemblies cover more than 99% of the...
by tunhnguy | May 8, 2023 | Publications
Abstract We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the...
by tunhnguy | May 8, 2023 | Publications
Abstract Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of...
by tunhnguy | Apr 4, 2023 | News, Publications
Indigenous peoples and local communities as partners in the sequencing of global eukaryotic biodiversity Abstract The aim to sequence, catalog, and characterize the genomes of all of Earth’s eukaryotic biodiversity is the shared mission of many ongoing large-scale...
by tunhnguy | Nov 29, 2022 | Publications
Modular automated microfluidic cell culture platform reduces glycolytic stress in cerebral cortex organoids Spencer T. Seiler, Gary L. Mantalas, John Selberg, Sergio Cordero, Sebastian Torres-Montoya, Pierre V. Baudin, Victoria T. Ly, Finn Amend, Liam Tran, Ryan N....
by rmiyatsu | Oct 21, 2022 | Publications
Abstract The current human reference genome, GRCh38, represents over 20 years of effort to generate a high-quality assembly, which has benefitted society1,2. However, it still has many gaps and errors, and does not represent a biological genome as it is a blend of...
